#4935 TYG INDEX CORRELATED WITH PPROGRESSION OF CHRONIC KIDNEY DISEASE IN METABOLIC DYSFUNCTION-ASSOCIATED FATTY LIVER DISEASE

Abstract Background and Aims Chronic kidney disease (CKD) is an established major risk factor for cardiovascular disease. Moreover, progression of CKD results in end-stage disease, increased death. The recently proposed metabolic dysfunction-associated fatty liver (MAFLD) has been suggested to better reflect developing CKD. This study aimed evaluate the association between triglyceride-glucose (TyG) index patients with MAFLD. Method In data from medical records database Gangnam Severance Hospital 2006 through 2020, a longitudinal analysis included participants MAFLD was diagnosed individuals hepatic steatosis at least one conditions as follows: 1) overweight or obese (defined body mass [BMI] ≥ 23 kg/m2), 2) type 2 diabetes mellitus, 3) two more abnormalities. Progression defined by reduction GFR ≥30% baseline. Logistic regression analyses were used determine TyG adjusting influence confounders. Results 4,286 patients, whom 582 had Mean age 51.49 ± 11.451 years. After age, sex, systolic blood pressure, fasting plasma glucose, CRP, LDL-cholesterol smoking status, associated [OR 1.760 (1.089-2.844), P = 0.021]. Conclusion demonstrated that significantly